Date: {{$ActivityAssignDate}}

Dear Dr. {{ $doctorName }},

Subject: : To participate in a cross-sectional survey on Demographics & Management Practices in Acid Peptic Disease

Acid peptic diseases result from distinctive but overlapping pathogenic mechanisms that typically involve acid effects on diminished mucosal defense. Conditions such as acid reflux, damage the esophageal mucosa, and also potentially cause laryngeal tissue injury with subsequent development of pulmonary symptoms. A peptic ulcer is histologically defined as a mucosal defect that extends to or beyond the muscularis mucosa, with mucosal damage due to pepsin and gastric acid secretion. Most ulcers occur in the stomach and proximal duodenum while less commonly in the lower esophagus, the distal duodenum, or the jejunum.

Acid-related disorders influence the quality of life and productivity of afflicted patients and are common and important causes of morbidity and mortality. The prevalence of GERD in India ranges from 7.6% to 30%, being < 10% in most population studies, and higher in cohort studies.

Peptic acid diseases arise from distinctive but overlapping pathogenic mechanisms but ultimately have a common mechanism of tissue injury from acid. Gastric hydrochloric acid secretion is modulated by neural and hormonal stimulation of receptors on the basolateral membrane, as well as by activation of enzymes located on the surface of parietal cells. Modern therapy is aimed at these physiological targets

The goals of therapy include relief of symptoms, enhancement of ulcer healing in the affected mucosa (esophagus, stomach, and duodenum), and prevention of recurrence. Milestones in the treatment of these diseases have included

• The discovery of the histamine H2-receptor and its functional antagonists


• Identification of the H+ K+-adenosine triphosphatase (H+K+-ATPase) enzyme and the development of proton-pump inhibitors (PPIs)


• Confirmation of H. pylori as a peptic ulcer causative agent with the subsequent development of effective antibiotic eradication regimens

This survey will help:

• To understand the demography of patients suffering from acid peptic disorders (APD) in India


• To understand the disease profile, its diagnosis, and the use of various acidneutralizing/suppressing medications in APD


• To understand the drug usage pattern of various acid-neutralizing/suppressing medications in the management of APD in different specialties in India


• To understand the different approaches in the management of APD in India

If you agree to participate, you must provide an assessment response, to the standard questionnaire form. A link will be provided for the same on your registered email address.

We trust you and we are partners in safe and effective drug therapy. In that spirit, we hope you will consent to participate in this survey.