Dear Dr. {{$doctorName}},
Survey to understand the usage of High Dose PPI through prescription behavior of physicians in India
Gastroesophageal reflux disease (GERD) is among the most common conditions seen in ambulatory clinics and its disease burden continues to rise. A cross-sectional survey of 1000 clinicians (specialist gastroenterologists and non-specialists) across India: About 39.2% and 37.1% of patients had reported GERD and PUD respectively whereas EE occurs in almost 10% of GERD patients.
Proton pump inhibitor (PPI) therapy is the mainstay pharmacologic management for GERD, although up to 40% of patients with suspected GERD derive inadequate symptom relief with PPI. While patients with PPI non-response may not have true GERD, to begin with, a subset of PPI non-responders will have PPI refractory GERD.
The management strategies for refractory GERD expand beyond PPIs to include other pharmacologic or invasive interventions. Since mechanisms of PPI refractory GERD are varied, the choice of management strategy should be personalized to the patient’s needs and mechanistic dysfunction. PPI refractory GERD is defined as the presence of persistent troublesome GERD symptoms and objective evidence of GERD despite optimized PPI therapy.
Data supporting the optimal duration and dose of a PPI trial mostly derives from studies assessing healing in erosive esophagitis which demonstrated higher rates of endoscopic healing of erosive esophagitis and heartburn symptom resolution with double dose PPI compared to single dose, and lower symptom relapse following eight weeks of PPI therapy compared with four weeks of therapy. Professional societies such as the American College of Gastroenterology and the American Gastroenterological Association recommend escalating to double-dose PPI if erosive esophagitis persists or symptoms are only partially controlled on single-dose PPI.
This survey is designed to understand the usage of high-dose PPI and its place in therapy along with the prescription behaviour of physicians in India.
If you agree to participate, you will need to respond to the survey questionnaire.
We hope you will consent to participate in this survey. If you do, please sign and return the enclosed reply along with your visiting card for the accuracy of records.
|
}}){kind=logo}