Subject : Participation in “Market Research survey On Anti-histamines and Clinical Aspects of Non- Sedating Oral Antihistamines”
Allergic rhinitis is one of the type I allergic diseases and IgE-mediated inflammation developing through exposure of the nasal mucosa to allergens. Treatments for allergic rhinitis could be divided into removal or avoidance of allergens, pharmaceutical treatment, immunotherapy, and surgical intervention. Anti-histamines targeting the histamine H1 receptor play an important role in improving and maintaining the quality of life of patients with allergic rhinitis.
TSecond-generation antihistamines do not cross blood brain barrier and are non-sedative. First- generation antihistamines inevitably exhibited central depressant/sedative activities.
Moreover, they showed low specificity and adverse reactions (thirst, urinary retention, tachycardia, etc.) due to effects such as anticholinergic effects. Anti-histamines for first-line therapy should not have central depressant/sedative activities.
Survey Rationale:
At present, there are significant gaps in understanding the clinical aspects of sedative properties of various oral anti-histamines
The lack of awareness, limited published clinical data in India makes it uncertain how significantly these issues exist and to what extent sedation due to anti histamines is impacting patients in Indian scenario. This survey will provide us information about the issue.
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