Date: {{$ActivityAssignDate}}

Dear Dr. {{ $doctorName }},


Subject: An observational cross-sectional survey to understand the management paradigm of bronchial asthma and role of various combination therapies of fixed-dose inhaled corticosteroids (ICS) and long- acting ẞ2 agonist (LABA) in Indian settings


Asthma is a complex multifactorial disease and has a significant impact on quality of life. The patient presents with respiratory symptoms such as wheezing, shortness of breath, chest tightness, and cough, which vary over time and in severity.1,2 Globally, the estimated burden of asthma in India is 34.3 million patients, accounting for 13.09% of the global population. In India, 13.2 per thousand deaths occur due to asthma compared to the global asthma burden, India has a three times higher death rate.3,4


For the management of asthma, today we have several different combinations of ICS+LABA. Some of these are once daily (ultra-long acting) or twice daily available in Indian market. Hence, this survey is planned to understand the management paradigm of bronchial asthma and role of various combination therapies of fixed-dose inhaled corticosteroids (ICS) and long-acting ẞ2 agonists (LABA) in Indian settings. Hence this survey is planned to understand management paradigm of bronchial asthma and role of various combination therapies of fixed dose inhaled corticosteroids (ICS) and long acting B2 agonist (LABA) in Indian settings.


As you will be spending some extra time to give your feedback on the questionnaire based on your clinical experience, we propose to pay you by cheque a professional fee of Rs {{$contractAmount}}, on receiving the completed Survey Questionnaire Form from you.


We trust you and we are partners in providing safe and effective drug therapy. In that spirit, we hope you will consent to participate in this study. If you do, please sign and return the enclosed reply along with your visiting card for the accuracy of records.


Yours truly,

Sun Pharmaceutical Laboratories Limited

Mr. Mohit Bhasin

Business Unit Head

Sun Pharma


References


1. GINA Report, Global Strategy for Asthma Management and Prevention (2023 update). Available at: https://ginasthma.org/wp-content/uploads/2023/07/GINA-2023-Full-report-23 07 06- WMS.pdf. Accessed on: 15-03-2024


2. Habib N, Pasha MA, Tang DD. Current Understanding of Asthma Pathogenesis and Biomarkers. Cells. 2022;11(17):2764.




3. Singh S, Salvi S, Mangal DK, Singh M, Awasthi S, Mahesh PA, Kabra SK, Mohammed S, Sukumaran TU, Ghoshal AG, Barne M, Sinha S, Kochar SK, Singh N, Singh U, Patel KK, Sharma AK, Girase B, Chauhan A, Sit N. Siddaiah JB, Singh V. Prevalence, time trends and treatment practices of asthma in India: the Global Asthma Network study. ERJ Open Res. 2022:8(2):00528-2021.


4. Ganai I, Saha 1, Banerjee P, Laha A, Sultana S, Sultana N, Biswas H, Moitra S, Podder S. In silico analysis of single nucleotide polymorphism (rs34377097) of TBXA2R gene and pollen induced bronchial asthma susceptibility in West Bengal population, India. Front Immunol.