Subject : : Research and Insights on Gastrointestinal Motility Disorders in Diabetic Patients (GLIDE Study)
Diabetes mellitus (DM) is commonly associated with gastrointestinal symptoms such as nausea, vomiting, diarrhea, abdominal pain and constipation. Diabetes affects almost all parts of the GI tract but the exact prevalence of diabetic gastroenteropathy is unclear.
In the esophagus, DM is associated with decreased baseline tone of lower esophageal sphincter (LES), possibly leading to increased gastroesophageal reflux disorder (GERD). DM has been linked both to rapid gastric emptying, especially in the early stages of the diseasei, and more commonly with delayed gastric emptying and gastroparesis. Impaired relaxation of the gastric fundus has been reported to be accountable for early satiety and dyspeptic symptoms. The effect of diabetes on small intestine and colonic functions is not as well studied.
Functional GI disorders are prevalent in the community hence the presentation of diabetic gastroenteropathy and functional disorders such as functional dyspepsia and irritable bowel syndrome overlap and cannot be distinguished on the basis of symptoms or medical history (i.e., diabetes) alone. In fact, examinations of small bowel biopsies from patients with diabetes revealed neuropathy and myopathy only in a minority of patients
Management of diabetic gastroenteropathy is complex and involves a multidisciplinary approach. This cross-sectional study will help to understand the overall disease burden of motility disorders in diabetic patients and non-pharmacological and pharmacological approaches in its management in India.
If you agree to participate, you will be required to respond to questions of the enclosed questionnaire. We trust you and we are partners in promoting safe and effective drug therapy. In that spirit we hope you will consent to participate in this study. If you do, please sign and return the enclosed reply along with your visiting card for accuracy of records.
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