Subject: To understand the usage of Natural Micronised Progesterone (NMP) including Oral NMP SR formulation in Threatened Abortion & Recurrent Pregnancy Loss (RPL)
Miscarriage is defined as the spontaneous loss of pregnancy before the fetus reaches viability. Miscarriage is a frequent outcome of pregnancy, with major emotional implications to the couple experiencing such an event. Threatened miscarriage is the commonest complication of early pregnancy and affects about 20% of pregnancies. It presents with vaginal bleeding with or without abdominal cramps. On the other hand recurrent miscarriages are post implantation failures in natural conception. Increasing age of women, smoking, obesity or polycystic ovary syndrome (PCOS) and a previous history of miscarriage are risk factors for threatened miscarriage.1 Progesterone, which is a female sex hormone, is secreted by the corpus luteum in the ovary to prepare the endometrium and to provide an adequate immune environment for the establishment of pregnancy. Low progesterone levels have been associated with an increased risk of first trimester miscarriage. It has been postulated that progesterone supplementation in the early weeks of pregnancy may help to establish a sufficient immune response in early pregnancy and to prevent miscarriages.2
Medications that mimic the action of progesterone are known as progestogens. Natural micronized progesterone is a natural and bioidentical progesterone.
We have planned a survey to assess the usage of Oral NMP in routine clinical practice.
We trust and we are partners in ensuring safe and effective drug therapy. In that spirit we hope you will consent to participate in this survey.
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