Subject : : A
retrospective, cross-sectional, observational survey study to
understand the role of Sodium Hyaluronate eye drops in
management of dry eye disease.
Dry eye
syndrome (DES) is a disorder of the preocular tear film that results
in damage to the ocular surface and is
associated with symptoms of ocular discomfort. DES is also called
keratoconjunctivitis sicca (KCS), keratitis sicca,
sicca syndrome, xerophthalmia, dry eye disease (DED), ocular surface
disease (OSD), or dysfunctional tear
syndrome (DTS), or simply dry eyes.1,2 Keratoconjunctivitis sicca is
a Latin word and its literal translation is
“dryness of the cornea and conjunctiva.” It may be helpful to know
that “sicca” is part of the English word “desiccate.”
1,3 The dry eye syndrome in which the eyes do not produce enough
tears is also known as “Sjogren’s syndrome”.
Dry eye disease is characterized by instability of the tear film
that can be due to insufficient amount of tear
production or due to poor quality of tear film, which results in
increased evaporation of the tears. Dry eye therefore
can mainly be divided into two groups, namely,
Aqueous
production deficient dry eye disease;
Evaporative dry eye disease
Evaporative dry eye disease
A key principle for the management of dry eye disease is
augmentation of the tear film through the topical
administration of artificial tear substitutes. These products
enhance tear stability thus reducing loss by evaporation;
this, in turn, helps to retain moisture in the eye and relieve the
chronic ocular inflammation associated with dry eyes.
Artificial tear substitutes help to reduce patient discomfort,
improve quality of life and reduce the risk of damage to
the corneal epithelium.
Artificial
tear drops are most commonly associated with the management of dry
eye disease (DED). Artificial tears
are typically included in first-line management options for dry eye,
as they are easy to use, accessible in a wide range
of formulations, and have a low risk-profile.
Hyaluronic
acid (HA) also known as Sodium hyaluronate (SH) a naturally
occurring high-molecular-weight
polysaccharide. HA is widely exists in various human tissues such as
the umbilical cord, vitreous humor, dermis
and epidermis.6 SH has great hygroscopic capacity that allows
retention of an amount of water up to 1,000 times its
own weight. This increases ocular surface wettability and reduces
tear evaporation. HA can significantly decrease
Oxidative stress, and inflammatory cytokines production. Also it can
protect corneal epithelial cells against UV
radiation, benzalkonium chloride (BAK) and daily person use products
like shampoos. Additionally, it can bind to
fibronectin and thereby it promotes epithelial migration and ocular
surface repair.
There is limited Indian evidence on the role of Sodium hyaluronate
eyedrops in management of dry eye disease,
hence this observational survey study aims to understand the role of
Sodium hyaluronate eyedrops in management
of dry eye disease
We invite you to participate in this data collection activity. All
you need to do is to report on a standard form your
experience with Sodium hyaluronate eyedrops in management of dry eye
disease, in the normal course of your
practice. If you agree to participate, you will need to fill data
collection forms (which we call DCF).
We trust you and we are partners in promoting safe and effective
drug therapy. In that spirit we hope you will consent
to participate in this study. If you do, please sign and return the
enclosed reply along with your visiting card for
accuracy of record.
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