Subject : A
multicentric, cross-sectional, observational survey study to
understand the role of 0.18% sodium hyaluronate and trehalose
eye drops in management of dry eye disease
Dry eye
syndrome (DES) is a disorder of the preocular tear film that results
in damage to the ocular surface and is associated
with symptoms of ocular discomfort. DES is also called
keratoconjunctivitis sicca (KCS), keratitis sicca, sicca syndrome,
xerophthalmia, dry eye disease (DED), ocular surface disease (OSD),
or dysfunctional tear syndrome (DTS), or simply dry
eyes.1,2 Keratoconjunctivitis sicca is a Latin word and its literal
translation is “dryness of the cornea and conjunctiva.”It may
be helpful to know that “sicca”is part of the English word
“desiccate.”The dry eye syndrome in which the eyes do not produce
1,3 enough tears is also known as “Sjogren’s
syndrome”.13
Dry eye
disease is characterized by instability of the tear film that can be
due to insufficient amount of tear production or due
to poor quality of tear film,which results in increased evaporation
of the tears.Dry eye therefore can mainly be divided into
two groups,namely,
-
aqueous production deficient dry eye disease;
-
evaporative dry eye disease1
Akey
principle for the management of dry eye disease is augmentation of
the tear film through the topical administration of
artificial tear substitutes. These products enhance tear stability
thus reducing loss by evaporation; this, in turn, helps to
retain moisture in the eye and relieve the chronic ocular
inflammation associated with dry eyes. Artificial tear substitutes
4
help to reduce patient discomfort,improve quality of life and reduce
the risk of damage to the corneal epithelium.4
Artificial
tear drops are most commonly associated with the management of dry
eye disease (DED). Artificial tears are
typically included in first-line management options for dry eye, as
they are easy to use, accessible in a wide range of
5
formulations,and have a low risk-profile.5
Hyaluronic
acid (HA) also known as Sodium hyaluronate (SH) a naturally
occurring high-molecular-weight
polysaccharide. HA is widely exists in various human tissues such as
the umbilical cord, vitreous humor, dermis and
epidermis.6 SH has great hygroscopic capacity that allows retention
of an amount of water up to 1,000 times its own weight.
This increases ocular surface wettability and reduces tear
evaporation.HAcan significantly decrease Oxidative stress, and
inflammatory cytokines production.Also it can protect corneal
epithelial cells against UVradiation, benzalkonium chloride
(BAK) and daily person use products like shampoos. Additionally, it
can bind to fibronectin and thereby it promotes
7
epithelial migration and ocular surface repair7
Trehalose, a commonly used ocular pharmaceutical agent,is a natural
disaccharide that has been shown to protect against
apoptosis, control inflammation, and maintain the integrity of the
cornea, conjunctival cells, and their intracellular
8 8
organelles.8 Previous clinical studies have demonstrated
the effectiveness of this combination in the treatment of
DED8
There is limited Indian evidence on the role of 0.18% sodium
hyaluronate and trehalose eyedrops in management of dry eye
disease, hence this observational survey study aims to understand
the role of 0.18% sodium hyaluronate eyedrops and
trehalose in management of dry eye diseas
We invite you to participate in this data collection activity. All
you need to do is to report on a standard survey form your
experience with 0.18% sodium hyaluronate and trehalose eyedrops in
management of dry eye disease,in the normal course
of your practice.If you agree to participate,you will need to fill
questionnaire based survey form.
We trust you and we are partners in promoting safe and effective
drug therapy. In that spirit we hope you will consent to
participate in this study. If you do, please sign and return the
enclosed reply along with your visiting card for accuracy of
records
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