Subject: To understand the in-clinic experience on the usage of 5-Methyl Tetrahydrofolate (Active form of Folate) during pregnancy, preconception period and lactation.
Folate is the generic term for vitamin B9, a water-soluble vitamin that includes chemically similar compounds essential in periods of rapid cell growth and division, in the maintenance of new cells, and in the making of DNA and RNA. It is also crucial for the regulation of Homocysteine in the body. Homocysteine regulation is very crucial during pregnancy as Hyperhomocysteinemia leads to multiple pregnancy related complications. Folate supplementation is also recognized for pregnancy and fertility support, recognition is growing that it also benefits cardiovascular health, mood, and cognition.
The bioavailability and metabolism of the different folate forms vary due to their respective chemical structures. All forms of folates, natural or synthetic, must be converted to the circulating form 5-MTHF to exert their biological activity. The structurally related compounds included in the folate group are FA, natural folates, and 5-MTHF.
5-MTHF: The biologically active form 5-MTHF, the predominant physiological form of folate found in blood and in umbilical cord blood, is also available in small amounts in foods. It’s widely available as a food ingredient and doesn’t require metabolization.
We have planned this survey to gain insights on the usage of the 5-Methyl Tetrahydrofolate (Active form of Folate) during pregnancy, preconception period and lactation.
We invite you to participate in this survey by responding to the survey questions and sharing your opinion on the role of 5-Methyl Tetrahydrofolate (Active form of Folate) in your routine clinical practice.
We trust you and we are partners in ensuring safe and effective therapy. In that spirit we hope you will consent to participate in this survey.
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