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10-25
25-50
>50
Any other
Stage 1
Stage 2
Stage 3
Stage 4
Stage 5
10-25 %
25-50 %
50-75%
>75%
Every 3 months
Every 6 months
Every month
Depends on clinical judgement
Avoiding or minimizing blood transfusions
Avoiding or minimizing anemia related symptoms
Avoiding or minimizing ESA therapy
Reduce tolerance and compliance of oral iron formulations due to gastrointestinal intolerance and constipation
All of the above
When oral iron treatment > 3 months is ineffective
In dialysis dependent CKD patients
In ND-CKD patients associated with severe Iron deficiency
Only IV iron
Both oral or IV Iron depending on the need
Only oral iron
<500 ng/ml
<700 ng/ml
500-700 ng/ml
Yes
No
In severe anemia not responding to oral iron therapy
In dialysis dependent anemia
To reduce the dose of ESAs
Efficacy
Safety profile
Patient preference
Cost-effectiveness
Oral Therapy
Hb<11.5g%
Hb 11.5 to <12g%
Hb≥12g%
Highly effective
Moderately effective
Slightly effective
Completely agree
Somewhat agree
Don’t agree
Long- Term clinical trials
Comparative studies with other treatments
Real – world data analysis
Regular blood test (Hb, etc)
Clinical symptoms
Both blood test and clinical symptoms
Once a week
Every 2 week
Every 3 week
Every 4 week
If yes