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<10%
10-20%
20-30%
>30%
<20%
30-40%
>40%
Symptoms
PH metry
Upper GI endoscopy
Impedance/PH metry
Any other
Yes
No
Weekly
Fortnightly
Monthly
20mg
40mg
80mg
4-6 weeks
6-8weeks
8-10 weeks
10-12 weeks
Proton Pump Inhibitor
Histamine 2 Receptors Antagonist
Prokinetics
Probiotics
Symptom assessment
Double dose of PPI
PPI plus prokinetics
Addition of other antacid medication
Dual-release formulation
1 weeks
2 weeks
2-4 weeks
>4 weeks
Patients who do not respond to a standard dose of PPI
Patients who do not respond to double doses of PPI
GERD patients with nausea and vomiting
Very much improved
Much improved
Minimally improved
No change
Minimally worse
Much worse
Very much worse
Drug-drug interactions
Relative efficacy
Long-term use safety
Food-drug interaction