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Achieving glycaemic control
Reducing cardiovascular risk
Reducing renal risk
Improving quality of life
Any Other
Every month
Every 3-6 months
Every 6-12 months
Once in a year
Poor patient adherence
Patients not adhering to lifestyle Modifications
Complexity of treatment regimens
Comorbidities along with T2DM
Sitagliptin
Dapagliflozin
Glimepiride
GLP-1 or insulin
Metformin monotherapy
Metformin + Dapagliflozin
Metformin + Sitagliptin
Metformin + Glimepiride
Metformin + Glimepiride + Sitagliptin
Metformin + Pioglitazone + Sitagliptin
Metformin + Glimepiride + Pioglitazone
Metformin + Glimepiride + Dapagliflozin
Based on patient's willingness to use multiple therapies
Based on patient's HbA1c level
Based on comorbidities
Efficacy in lowering HbA1c
Cost-effectiveness
Fewer side effects
to improve patient’s compliance and adherence by fixed dose combination
Reduce the dose from 1000mg to 500 mg
Switch to extended-release metformin
Advise taking it with meals
Discontinue metformin
Hypoglycemia
Gastrointestinal issues
Weight gain
None
1 month
2 months
3 months
More than 3 months
initiated with low dose of glimepiride
Educate patients for symptoms of hypoglycemia
Frequent blood glucose monitoring
All of the above
More effective and better adherence
Similar efficacy but safety concerns
More effective but safety concerns
Less effective and poorer adherence
Adding insulin
Adding another oral antidiabetic drug
Intensifying lifestyle modifications
Initiated with lower doses
Frequent monitoring
Adjusting doses of other anti-diabetic medications
Simplifying the treatment regimen by administering FDCs
Persistent high HbA1c
Frequent hypoglycemia
Patient preference
Development of complications
Patient education
Simplifying treatment regimens
Regular follow-up appointments
Very satisfied
Satisfied
Neutral
Dissatisfied
Medical journals
Conferences and seminars
Online courses
Peer discussions