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A survey to understand the overall treatment landscape of partial onset seizure with focus on lacosamide.

Survey Questionnaire Form
Doctor's details
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Questionnaire
I. General / Demographics
  1. What is the average number of epilepsy patients you manage monthly in your clinical practice? *
  2. What is the average number of patients with focal-onset seizures (FOS) you manage monthly in your clinical practice? *
  3. In your clinical experience, which age group is most frequently diagnosed with focal-onset epilepsy? *
  4. What comorbidities are frequently associated with partial onset seizures in your patients? *
  5. What are the major challenges in managing partial onset seizures in Indian settings? *
  6. II. Lacosamide Usage Patterns (Dose, Initiation, Maintenance, Titration, Indications)
  7. What is your typical initial dose of lacosamide (LCM) as adjunctive for adult patients with FOS? *
  8. What is the typical duration required to titrate LCM to the therapeutic maintenance dose in adult patients with FOS? *
  9. What is the most common maintenance dose of LCM as adjunctive you prescribe for adult patients with FOS? *
  10. Describe the clinical characteristics of patients with FOS you consider ideal candidates for initiating LCM therapy. *
  11. How do you titrate LCM dose in elderly patients with FOS, including considerations for comorbidities (renal/hepatic impairment)? *
  12. In which clinical scenario do you most commonly administer intravenous (IV) LCM? *
  13. Under what conditions do you typically transition patients from IV to oral LCM? *
  14. How would you rate the transition of lacosamide from IV to oral LCM? *
  15. What are the primary factors influencing your decision to prescribe LCM for FOS? *
  16. In your treatment algorithm for focal epilepsy, where do you position LCM? *
  17. Do you prescribe lacosamide for partial onset seizures in pregnant women? *
  18. What is the maximum dose of lacosamide you prefer in patients with hepatic dysfunction? *
  19. What strategies do you employ to optimize patient adherence to LCM therapy in FOS management? *
  20. How would you rate patient adherence to LCM therapy based on your clinical experience? *
  21. III. Efficacy of Lacosamide
  22. Based on your clinical observations, how would you categorize the efficacy of LCM in achieving seizure control in patients with FOS? *
  23. In your experience, what is the typical time to observe a clinically meaningful response to adjunctive LCM therapy in patients with FOS? *
  24. What proportion of your patients with FOS achieve a clinically significant reduction in seizure frequency following LCM initiation? *
  25. How frequently do your patients achieve seizure freedom with LCM therapy? *
  26. In your clinical practice how does LCM compare to first-generation antiseizure medications (ASMs) in the management of FOS in terms of efficacy and safety? *
  27. Which ASM, when combined with LCM, demonstrates the most significant synergistic effect in controlling FOS? Please specify and describe the observed clinical benefit. *
  28. How effective is LCM in reducing seizure frequency within the first 3 months of therapy in your patients with FOS? *
  29. Does adjunctive LCM therapy allow for dose reduction of concomitant first-line ASMs in your patients? *
  30. How does LCM add-on therapy impact the frequency of seizure-related hospital admissions in your patients with FOS? *
  31. How frequently do your patients report an improved quality of life following LCM initiation? *
  32. What is the overall patient satisfaction with LCM regarding seizure control and tolerability? *
  33. How would you describe the efficacy and tolerability of lacosamide (LCM) compared to other antiseizure medications (ASMs) when used as a first add-on therapy in the management of focal-onset seizures (FOS)? *
  34. How effective is LCM as 1st add-on to incomplete response in FOS patients? *
  35. How effective is LCM in managing drug-resistant FOS in your clinical practice? *
  36. How effective do you find lacosamide as an add-on therapy in focal onset seizures? *
  37. IV. Safety of Lacosamide
  38. Do you observe any common adverse effects of lacosamide? If yes, what are the most frequent adverse effects you encounter? *
  39. How does the severity of LCM-related adverse effects compare to other ASMs in your experience? *
  40. Compared to levetiracetam, how does LCM perform in terms of cognitive adverse effects in your patients with FOS? *
  41. How does LCM compare to other ASMs in terms of drug-drug interactions? *
  42. V. Tolerability / Cognitive Effects
  43. How would you rate the overall tolerability of LCM in patients with FOS? *
  44. When LCM is added to levetiracetam, does it mitigate behavioral adverse effects in your patients? *
  45. How would you rate the cognitive side effect profile of lacosamide compared to other anti-seizure medications? *
  46. How does LCM’s cognitive adverse effect profile compare to other ASMs in your experience? *