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Increased abdominal obesity
Faster progression from pre diabetes to diabetes
Decreased adiponectin and increased inflammatory markers
Faster onset of beta cell dysfunction
Possible increase of DPP4 activity
Increased susceptibility for cardio-renal complications
High level of A1c (>8%) at entry level
Uncontrolled T2DM on existing therapy
Uncontrolled T2DM with comorbidities
For early intensification of diabetes management in young diabetic patients
Yes
No
Can't say
Similar
Greater CKD risk
Greater Heart Failure risk
Less than 10%
10 – 20%
20 – 30%
30 – 50%
More than 50%
1
2
3
Less than 40 years
40 to 50 years
50 to 60 years
60 years and above
Age group does not matter
Dapagliflozin
Empagliflozin
Canagliflozin
Remogliflozin
Sitagliptin
Vildagliptin
Linagliptin
Teneligliptin
DPP4
SGLT2i
SU
DPP4 Inhibitors
SGLT2 Inhibitors
<25%
25-50%
50-75%
>75%
0 – 15%
16 – 30%
31 – 45%
>45%
Targeting multiple pathophysiological factors as never before
Ensuring durable glycemic control with preservation of beta-cell mass
Good possibility of additional cardio-renal protection
Better compliance and adherence to the therapy
Not at all LikelyExtremely likely
Aggressive HbA1c control
Optimal management of T2DM and prevention of microvascular events
Beta-cell preservation as dose of SU can be optimized
Low risk of hypoglycemia & weight gain
Patient convenience & compliance