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Shortness of breath, especially when lying down
Swelling in feet, ankles, and legs
Both of the above
None of the above
High Blood Pressure
Heart and Lung Problems
Lifestyle and Infections
All of the above
Follow health care professional’s advice
Quit smoking and avoid or limit alcohol and caffeine
Take your medications exactly as prescribed
Follow a heart-healthy diet
Beta blocker
SGLT2 i
ARNI/ACE i
MRA’s
Yes
No
Conventional, stepped approach
Rapid sequencing followed by up titration
Simultaneous initiation, rapid titration
Sacubitril/Valsartan 50
Sacubitril/Valsartan 75
Sacubitril/Valsartan 100
Sacubitril/Valsartan 200
Low blood pressure to add new medications
Low enough blood pressure/heart rate to titrate medications
Hyperkalemia
Clinical time constraints
5%
10%
20%
30%
>30%
Strongly agree
Agree
Neutral
Disagree
Torsemide
Captopril
Carvedilol
Atenolol
True
False
Decrease in fasting plasma glucose and glycosylated hemoglobin
Increase in insulin sensitivity
Both a and b
None
Reduction in systolic and diastolic BP
Reduction in left ventricular mass and sphericity
Increase in coronary flow reserve
Increased renal blood flow
Reduction in microalbuminuria
Slows worsening of heart failure
Improves heart failure symptoms
Improves ejection fraction
Established clinical efficacy
Favorable safety profile
Pure heart-rate lowering capacity
Reduce risk of HF hospitalization or cardiovascular death in symptomatic patients
Sinus rhythm with resting HR at least 70 bpm, in spite of treatment with β-blocker, ACEi (or ARB) and an MRA
Pharmacokinetic profile that produces predictable anticoagulation responses
Does not undergo CYP 450 metabolism
Has few drug–drug and drug–food interactions
Does not require frequent laboratory monitoring of clotting parameters