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TrafolicTM Survey
(Quatrefolic + Pyridoxal-5-Phosphate + Cyanocobalamin + Glycine)
       (6S)-5-methyltetrahydrofolic is better alternative to Folic Acid

    Supplementation with (6S)-5-methyltetrahydrofolic acid appears as effective as folic acid in maintaining maternal folate status while reducing unmetabolized folic acid in maternal plasma. Folic acid supplementation is recommended during pregnancy to support healthy fetal development; (6S)-5-methyltetrahydrofolic acid ((6S)-5- MTHF) is available in some commercial prenatal vitamins as an alternative to folic acid, but its effect on blood folate status during pregnancy is unknown. To address this, we randomised sixty pregnant individuals at 8–21 weeks’ gestation to 0•6 mg/d folic acid or (6S)-5-MTHF × 16 weeks. Fasting blood specimens were collected at baseline and after 16 weeks.

    Please read the full text of the article here - https://pubmed.ncbi.nlm.nih.gov/37649241/
  1. How many newly diagnosed pregnant females do you usually see in your clinical practice in a month? *

  2. In your practice, do you give folic acid supplementation to all the pregnant females? *

  3. In your practice, in which trimester of pregnancy do you usually start folic acid supplementation? *

  4. Which of the following folic acid preparation do you usually prefer in pregnancy? *

  5. In your opinion, what are the common maternal complications of folate deficiency? *

  6. In your opinion, what are the common fetal/newborn complications of folate deficiency? *

  7. Do you give Trafolic to pregnant females in your clinical practice? *

  8. In your practice, do you give folic acid supplementation during preconception period? *

  9. When do you usually start usually start folic acid supplementation in the preconception period? *

    10.    Active Folate Versus Folic Acid

    Testing every pregnant woman for the existence of a mutated MTHFR gene isn’t a standard medical protocol, but women expressing MTHFR polymorphism may not experience the perceived advantage of FA supplementation and can be at potential risk because they are less able to transform FA. Because the association between the MTHFR polymorphism and a low folate concentration has been assessed, the direct supplementation of an active form, such as Quatrefolic (5-MTHF), through fertility supplements, prenatal vitamins, and dietary supplements, should be strongly considered as being universally beneficial.

    Please read the full text of the article here – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9380836/
  10. Which of the following folic acid preparation do you usually prefer during preconception period? *

  11. In your practice, do you give Trafolic during preconception period? *

  12. In your practice, do you give folic acid supplementation during lactation? *

  13. In your practice, till when do you usually give folic acid supplementation post pregnancy during lactation? *

  14. Which of the following folic acid preparation do you usually prefer during lactation? *

  15. In your practice, do you give Trafolic during lactation? *

  16. How will you rate the effectiveness of Trafolic? *

  17. How will you rate the tolerability of Trafolic? *

  18. How will you rate the patient compliance of Trafolic? *

  19. In your clinical practice, for which of the following reasons do you prefer Trafolic supplementation? *

  20. In your opinion, in which trimester of pregnancy should folic acid supplementation in combination with docosahexaenoic acid (DHA) be started? *