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Male Female
>60 mL/min/1.73m2
>45 mL/min/1.73m2
>30 mL/min/1.73m2
>15 mL/min/1.73m2
Early – Stage 1 and II
Moderate – Stage III and IV
At all stages from I to IV
Any Other
All
>50%
> 25-50%
<25%
Offer additive benefits due to different mechanisms of action
Don’t see additional benefit of administering Finerenone and SGLT2i together
Finerenone and SGLT2i together may lead to safety concerns
>20%
>40%
>60%
>80%
25 to % 50 %
10-25%
<10%
CKD stage >3
CKD stage >4
Heart failure
Usage of concomitant drug classes (ARBs/ACEi/MRAs/NSAIDs) that cause hyperkalemia
>5.5
>6
>6.5
Only if patient is symptomatic
<10 %
20-30%
40-50%
<5%
5-10%
11-20%
All Together
Sequential
Depending upon the patients profile
Based on eGFR level
10-20%
20-40%
Yes
No
>25%
>75%
1-2 patients
3-5 patients
6-10 patients
> 50% of patients
> 30% of patients
>20% of patients
< 20% of patients
>30%
30-40%
> 50%
Statins
Statins + Low Dose Aspirin
Statins + Low dose Aspirin + Non-Vitamin K Antagonist Oral Anticoagulants